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. 2018 Jun 27;8:9754. doi: 10.1038/s41598-018-28137-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological aspects of the brain and cerebellum tissues of DENV-infected mice. (A) Cerebral cortex of a mock-inoculated mouse exhibiting normal aspects; (B) Mouse infected with DENV-2 showing pia mater with inflammatory infiltrate; (C) focal perivascular inflammatory infiltrate on the 2^nd d.p.i and (D) diffuse inflammatory infiltrate on the 7^th d.p.i. (E) Normal white matter from a mock-inoculated mouse. (F) White matter committed with inflammatory infiltrate on the 2^nd d.p.i and (G) on the 7^th d.p.i. (H) CA1 and (I) CA3 hippocampal regions from a mock-inoculated mouse. (J) Microglial cell infiltrate in CA1 on the 2^nd d.p.i and (K) in CA3 on the 7^th d.p.i. (L) Cerebellum region with normal aspects extracted from a control mouse. (M) Degenerated Purkinje neuronal layer on the 2^nd d.p.i. (N) Demyelination with microglial cell infiltrate and (O) hemorrhage on the 7^th d.p.i. CA1 - Cornu ammonis 1 region; CA3 - Cornu ammonis 3 region; D - demyelination; DG - dentate gyrus; GL - granular layer; H - hippocampus; He - hemorrhage; ML - molecular layer; OR - orien; PL - pyramidal layer; PM - pia mater; Inf - Inflammatory infiltrate; PN - Purkinje neuron; Mi - Microglia; WM - white matter; d.p.i. - days post infection.