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. 2018 Jun 27;8:9754. doi: 10.1038/s41598-018-28137-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of DENV-NS3 protein in brain and cerebellum tissues. DENV-NS3 protein was detected using immunohistochemistry on brain and cerebellum cuts. Regions of (A) cerebral cortex, (D) hippocampus and (H) cerebellum from samples of control mice showing negative staining reaction for DENV-NS3. Samples from infected animals showing detection of DENV-NS3 in: (B) endothelial and (C) microglial cells located at the cerebral cortex on the 2^nd and 7^th d.p.i., respectively; (E,F) microglial/endothelial cells and (G) granular cells of the hippocampus on the 2^nd and 7^th d.p.i., respectively; (I,J) Purkinje neurons/microglial cells and (K,L) neurons/endothelial cells on the 2^nd and 7^th d.p.i., respectively. EC - endothelial cell; Mi - microglial cells; Gc - granular cells; PN - Purkinje neurons; Neu - neurons; d.p.i. - days post infection.