Table 3.
Effects of ion channel blockers on firing patterns sensitive and resistant to synaptic block.
| After Synaptic Blockade | Without Synaptic Blockade | |||||
|---|---|---|---|---|---|---|
| ZD7288 | Riluzole | Riluzole + ZD | ZD7288 | Riluzole | Riluzole + ZD | |
| IS | 2/3 (66%) | 3/3 (100%) | 3/3 (100%) | 34/41 (83%) | 21/31 (68%) | 23/24 (96%) |
| ISB | — | — | — | 8/10 (80%) | 4/4 (100%) | 3/3 (100%) |
| IFB | — | — | — | 7/8 (87%) | 14/18 (78%) | 6/7 (86%) |
| Mixed | 1/1 (100%) | 0/1 (0%) | 1/1 (100%) | 1/1 (100%) | 0/4 (0%) | — |
| All Irregular | — | — | — | 50/60 (83%) | 39/57 (68%) | 32/34 (94%) |
| RS | 13/18 (72%) | 6/12 (50%) | 11/12 (91%) | 3/3 (100) | 3/6 (50%) | 4/4 100%) |
| RSB | 4/5 (80%) | 4/8 (50%) | 7/8 (87%) | 2/2 (100%) | 0/3 (0%) | 2/2 (100%) |
| RFB | — | — | — | — | 1/2 (50%) | 1/1 (100%) |
| All Regular | 17/23 (73%) | 10/20 (50%) | 18/20 (90) | 5/5 (100%) | 4/11(36%) | 7/7 (100%) |
| Totals | 20/27 (74%) | 13/24 (54%) | 22/24 (91%) | 55/65 (84%) | 43/68 (63%) | 39/41 (95%) |
Number of inhibited/group total neurons after application of ZD7288, riluzole or a combination of both. Data on riluzole and riluzole + ZD columns obtained sequentially from some experiments.