Table 2.
Changes in bacterial populations from the time of surgery to follow up endoscopy in subjects with recurrence and remission.
| Population | Surgical specimen in recurrent subjects (SD) n = 9 | 6-month post-ICR specimen in recurrent subjects (SD) n = 9 | p-value | FDR-adjusted p-value | Surgical specimen in remission subjects (SD) n = 15 | 6-month post-ICR specimen in remission subjects (SD) n = 15 | p-value | FDR-adjusted p-value |
|---|---|---|---|---|---|---|---|---|
| Phylum | ||||||||
| Proteobacteria | 40.7% (37.6%) |
19.4% (21.7%) |
0.18 | 0.36 | 30.2% (31.7%) |
27.0% (22.9%) |
0.65 | 0.97 |
| Bacteroidetes | 36.3% (32.4%) |
65.0% (30.4%) |
0.08 | 0.24 | 44.8% (31.3%) |
31.5% (32.0%) |
0.10 | 0.30 |
| Firmicutes | 20.9% (19.7%) |
15.0% (20.6%) |
0.51 | 0.51 | 23.0% (22.5%) |
39.8% (31.7%) |
0.04 | 0.16 |
| Actinobacteria | 1.2% (1.0%) |
0.3 (0.3%) |
0.04 | 0.16 | 1.1% (1.8%) |
1.1 (1.7%) |
0.97 | 0.97 |
| Class | ||||||||
| Bacteroidia | 35.1% (33.7%) |
64.5% (30.5%) |
0.08 | 0.40 | 43.5% (31.8%) |
29.9% (32.2%) |
0.10 | 0.40 |
| Clostridia | 11.0% (7.8%) |
13.9% (20.9%) |
0.66 | 0.66 | 20.5% (19.9%) |
36.5% (30.6%) |
0.04 | 0.20 |
| Gammaproteobacteria | 37.0% (36.5%) |
17.3% (21.1%) |
0.20 | 0.58 | 25.4% (30.8%) |
20.9% (19.3%) |
0.48 | 0.56 |
| Bacilli | 7.2% (14.6%) |
0.7% (1.2%) |
0.23 | 0.58 | 2.0% (3.3%) |
1.4% (2.2%) |
0.56 | 0.56 |
| Alphaproteobacteria | 2.6% (2.4%) |
1.6% (1.1%) |
0.29 | 0.58 | 2.2% (6.2%) |
4.0% (6.0%) |
0.45 | 0.56 |
| Order | ||||||||
| Bacteroidales | 35.1% (33.7%) |
64.5% (30.5%) |
0.08 | 0.48 | 43.5% (31.8%) |
29.9% (32.2%) |
0.10 | 0.50 |
| Clostridiales | 11.0% (7.8%) |
13.9% (20.9%) |
0.66 | 0.66 | 20.5% (19.9%) |
36.5% (30.6%) |
0.04 | 0.24 |
| Enterobacteriales | 35.4% (27.9%) |
16.6% (21.5%) |
0.22 | 0.66 | 25.0% (30.8%) |
17.7% (15.6%) |
0.34 | 0.68 |
| Rhizobiales | 2.2% (2.5%) |
1.6% (1.1%) |
0.54 | 0.66 | 1.6% (4.1%) |
3.9% (5.8%) |
0.25 | 0.68 |
| Lactobacillales | 7.1% (14.4%) |
0.7% (1.2%) |
0.23 | 0.66 | 1.9% (3.2%) |
1.3% (2.2%) |
0.48 | 0.68 |
| Burkholderiales | 1.1% (1.6%) |
0.5% (0.7%) |
0.30 | 0.66 | 2.5% (3.7%) |
2.0% (3.0%) |
0.68 | 0.68 |
| Family | ||||||||
| Bacteroidaceae | 32.7% (31.1%) |
61.4 (29.8%) |
0.07 | 0.28 | 36.0% (28.9%) |
28.2% (32.4%) |
0.29 | 0.34 |
| Enterobacteriaceae | 35.4% (37.9%) |
16.6% (21.5%) |
0.22 | 0.44 | 25.0% (30.8%) |
17.7% (15.6%) |
0.34 | 0.34 |
| Lachnospiraceae | 5.7% (5.0%) |
5.4% (6.5%) |
0.85 | 0.85 | 9.7% (7.2%) |
23.8% (21.3%) |
0.02 | 0.08 |
| Streptococcaceae | 6.7% (13.7%) |
0.3% (0.4%) |
0.20 | 0.44 | 1.2% (1.7%) |
0.6% (1.1%) |
0.13 | 0.34 |
All values calculated using the Student paired t-test. FDR- corrected q-values derived using Benjamini-Hochberg procedure.