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. 2018 Jun 27;8:9738. doi: 10.1038/s41598-018-28063-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Visualisation the interaction between the different biological processes (circles) regulated after exposure to E171 (octagon) for 2, 7, 14 and 21 days. Network created with Cytoscape. Only seen in the CRC mouse model in combination with E171 are in red, the ones only seen in the mice solely exposed to E171 are in blue¹⁶, and the ones in common between the previous 2 exposures are in blue and red.