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. 2018 Jun 27;8:9738. doi: 10.1038/s41598-018-28063-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scheme of exposure of experimental mouse model. BALB/c mice (n = 32) were randomly distributed in 2 groups (16 per group) and were kept one week under acclimation conditions. Both the control and exposure group received a single intraperitoneal injection 12.5 mg/kg of AOM a week before the start of the experiment and DSS 2% dissolved in water ad libitum between day 1 and 5 respectively (light grey line). From day 1 to 21, E171 group received 5 mg/kg body weight by oral gavage of E171 dispersed in water 5 days per week (black line). The control group kept on receiving a vehicle (sterile water). *2 males and 2 females were sampled.