Table 1.
Affinity values of CB compounds obtained from radioligand binding assays.
| [3H]-CP-55940 competition binding experiments | [3H]-WIN-55,212-2 competition binding experiments | |||
|---|---|---|---|---|
| CB1 – KD (nM) | CB2 – KD (nM) | CB1 – KD (nM) | CB2 – KD (nM) | |
| 0.29 ± 0.02 | 0.32 ± 0.02 | 9.43 ± 0.83 | 3.16 ± 0.24 | |
| CB1 – Ki (nM) | CB2 – Ki (nM) | CB1 – Ki (nM) | CB2 – Ki (nM) | |
| WIN-55,212-2 | 8.08 ± 0.65 | 3.22 ± 0.31 | 9.86 ± 0.84 | 3.48 ± 0.27 |
| CBG | 1,045 ± 74 | 1,225 ± 85 | >30,000 | 2,656 ± 130 |
| CBD | 1,690 ± 110 | 1,714 ± 70 | >30,000 | 4,019 ± 342 |
KD values were obtained from saturation isotherms and Ki from data in competition assays using the indicated radiolabelled compounds ([3H]-CP-55940 or [3H]-WIN-55,212-2).