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. 2018 Jun 21;9:333. doi: 10.3389/fendo.2018.00333

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Copyright © 2018 Leifheit-Nestler, Richter, Basaran, Nespor, Vogt, Alesutan, Voelkl, Lang, Heineke, Krick and Haffner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum Fgf23 levels and cardiac Fgf23 expression are elevated in Hyp and kl/kl mice. (A) Increased serum C-term Fgf23 levels in both Hyp and kl/kl mice as compared to respective wild-type mice. (B) Elevation of intact Fgf23 concentrations in the serum of Hyp and kl/kl mice than in respective control mice. (C) Fgf23 mRNA levels are increased in cardiac tissue of both mouse lines demonstrated by quantitative real-time PCR after normalization to Gapdh. (D) Representative immunoblot and respective quantification show the elevation of Fgf23 protein levels in total heart lysates of Hyp and kl/kl animals (Gapdh served as loading control). Values are presented as mean ± SEM; numbers in each bar graph represent the n-values used for the respective measurement; *P < 0.05, **P < 0.01, ****P < 0.0001.