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. 2018 Jun 21;9:333. doi: 10.3389/fendo.2018.00333

Figure 4.

Figure 4

Kl/kl mice show an upregulation of cardiac pro-hypertrophic nuclear factor of activated T cell target genes. (A,B) Rcan1 expression is increased only in cardiac tissue from kl/kl mice demonstrated by quantification of mRNA levels by real-time PCR and protein levels by western blotting. (C) Quantification of bMHC and aMHC mRNA expression shows the induction of fetal gene program in heart tissue from kl/kl mice but not from Hyp mice. (D) ANP mRNA expression is induced in the myocardium of kl/kl mice in relation to respective wild-type animals. (E) Cardiac BNP mRNA expression is reduced in Hyp mice, but upregulated in kl/kl mice. Values are presented as mean ± SEM; numbers in each bar graph represent the n-values used for the respective measurement; *P < 0.05, **P < 0.01.