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. 2018 Jun 21;9:333. doi: 10.3389/fendo.2018.00333

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Copyright © 2018 Leifheit-Nestler, Richter, Basaran, Nespor, Vogt, Alesutan, Voelkl, Lang, Heineke, Krick and Haffner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different mineral metabolism between Hyp and kl/kl mice. (A) Serum calcium levels are normal to slightly reduced in Hyp mice and elevated in kl/kl animals. (B) Hyp mice are hypophosphatemic and kl/kl mice display hyperphosphatemia. (C) Serum parathyroid hormone (PTH) levels in Hyp mice are extensively elevated. For kl/kl mice, the PTH levels in the serum were not available (n.a.). (D) Renal Klotho mRNA expression is reduced in Hyp mice than in respective wild-type mice and barely detectable in kl/kl mice. Values are presented as mean ± SEM; numbers in each bar graph represent the n-values used for the respective measurement; **P < 0.01, ****P < 0.0001.