Table 2.

Differences between Hyp and kl/kl mice regarding characteristics of cardiovascular and kidney disease, cardiac FGF23/FGFR4 system, and parameters of mineral metabolism.

Characteristics	Hyp mouse	kl/kl mouse
Cardiac hypertrophy	–	+
Cardiac fibrosis	–	+
Kidney injury (48, 49)	–	–
Blood pressure (44, 50)	↑	↓
Calcification (44, 51)	–	+
Serum Fgf23	↑	↑↑
Cardiac Fgf23	↑	↑
Cardiac Fgfr4	↔	↑
Renal klotho	↓	↓↓
Serum calcium	↔ ↓	↑
Serum phosphate	↓	↑
Serum parathyroid hormone (44, 51)	↑	↓
Serum 1,25D (37, 44, 51)	↓	↑↑