Figure 1.

Representative examples of neuroimaging protocols acquired in Down syndrome. Panels (A–D) show MR imaging in a 57 year old male and 59 year old male imaged with T2^* (A, C) and FLAIR (B, D) showing the presence of microbleeds. Arrows distinguish edema and hemosiderin positive microbleeds. Panel (E) shows examples of amyloid PiB-PET imaging (top) and FDG-PET imaging (bottom). Images from (A–D) were modified from Figure 5 with permission of Elsevier Press (Head et al., 2018). Images from (E) were modified from Figure 1 reproduced with permission from Dr. M. Rafii and under the Creative Commons Attribution License (CC BY) (Rafii et al., 2015).