Table 3.
Receiver operating characteristic (ROC) curve analyses of the protein expression combining two biomarkers.
| CHI3L1 | IL-10 | IL-8 | PI3 | POSTN | MSR1 up | MSR1 low | PHLDA1 | SERPINB2 | |
|---|---|---|---|---|---|---|---|---|---|
| (A) Total nonallergic asthma (NA) group compared with the control group | |||||||||
| CHI3L1 | 0.60 | 0.48 | 0.67 | 0.59 | 0.63 | 0.78 | 0.97 | 0.70 | 0.92 |
| IL-10 | – | 0.42 | ND | 0.59 | 0.47 | ND | ND | ND | ND |
| IL-8 | – | ND | 0.50 | 0.61 | 0.74 | ND | ND | ND | ND |
| PI3 | – | – | – | 0.50 | 0.67 | 0.63 | 0.96 | 0.47 | 0.91 |
| POSTN | – | – | – | – | 0.62 | 0.73 | 0.96 | 0.82 | 0.95 |
| MSR1 up | – | ND | ND | – | – | 0.60 | 1 | ND | ND |
| MSR1 low | – | ND | ND | – | – | – | 0.96 | ND | ND |
| PHLDA1 | – | ND | ND | – | – | ND | ND | 0.42 | ND |
| SERPINB2 | – | ND | ND | – | – | ND | ND | ND | 0.91 |
| (B) Moderate–mild NA group compared with the control group | |||||||||
| CHI3L1 | 0.56 | 0.41 | 0.63 | 0.56 | 0.70 | 0.83 | ND | ND | 0.97 |
| IL-10 | – | 0.41 | ND | 0.67 | 0.63 | ND | ND | ND | ND |
| IL-8 | – | ND | 0.62 | 0.76 | 0.87 | ND | ND | ND | ND |
| PI3 | – | – | – | 0.51 | 0.69 | 0.61 | ND | ND | 0.89 |
| POSTN | – | – | – | – | 0.69 | 0.81 | ND | ND | 0.97 |
| MSR1 up | – | ND | ND | – | – | 0.60 | ND | ND | ND |
| MSR1 low | ND | ND | ND | ND | ND | ND | 1 | ND | ND |
| PHLDA1 | ND | ND | ND | ND | ND | ND | ND | 0.48 | ND |
| SERPINB2 | – | ND | ND | – | – | ND | ND | ND | 0.89 |
| (C) Severe NA group compared with the control group | |||||||||
| CHI3L1 | 0.63 | 0.62 | 0.67 | 0.63 | 0.64 | 0.76 | 0.94 | ND | 0.93 |
| IL-10 | – | 0.56 | ND | 0.51 | 0.60 | ND | ND | ND | ND |
| IL-8 | – | ND | 0.62 | 0.46 | 0.57 | ND | ND | ND | ND |
| PI3 | – | – | – | 0.52 | 0.65 | 0.64 | 0.95 | ND | 0.93 |
| POSTN | – | – | – | – | 0.55 | 0.66 | 0.93 | ND | 0.97 |
| MSR1 up | – | ND | ND | – | – | 0.60 | 1 | ND | ND |
| MSR1 low | – | ND | ND | – | – | – | 0.93 | ND | ND |
| PHLDA1 | ND | ND | ND | ND | ND | ND | ND | 0.48 | ND |
| SERPINB2 | – | ND | ND | – | – | ND | ND | ND | 0.93 |
| (D) Moderate–mild NA group compared with the severe group | |||||||||
| CHI3L1 | 0.62 | 0.43 | 0.76 | 0.56 | 0.77 | 0.68 | 0.65 | ND | 0.63 |
| IL-10 | – | 0.47 | ND | 0.63 | 0.77 | ND | ND | ND | ND |
| IL-8 | – | ND | 0.76 | 0.82 | 0.78 | ND | ND | ND | ND |
| PI3 | – | – | – | 0.55 | 0.57 | 0.60 | 0.60 | ND | 0.73 |
| POSTN | – | – | – | – | 0.65 | 0.64 | 0.62 | ND | 0.90 |
| MSR1 up | – | ND | ND | – | – | 0.46 | 0.55 | ND | ND |
| MSR1 low | – | ND | ND | – | – | – | 0.55 | ND | ND |
| PHLDA1 | ND | ND | ND | ND | ND | ND | ND | 0.48 | ND |
| SERPINB2 | – | ND | ND | – | – | ND | ND | ND | 0.70 |
In bold are the area under the curve values greater than 0.75, which are considered good, very good, or excellent tests. ND: non-determined because of lack of data. Cells with a dash refer to a comparison already shown in another cell of this table. MSR1 low: MSR1’s lower band protein expression. MSR1 up: MSR1’s upper band protein expression. In gray are indicated the individual ROC curve analysis of the protein expression of the nine biomarkers.