Table 4.
Receiver operating characteristic (ROC) curve analysis of the protein expression combining three biomarkers.
| (A) NA compared with the C | |||
|---|---|---|---|
| Combination of biomarkers | NA vs C area under the curve (AUC) value | MM vs C AUC value | S vs C AUC value |
| CHI3L1 + IL-10 + PI3 | 0.59 | 0.67 | 0.64 |
| CHI3L1 + IL-10 + POSTN | 0.53 | 0.63 | 0.64 |
| CHI3L1 + IL-8 + PI3 | 0.67 | 0.79 | 0.79 |
| CHI3L1 + IL-8 + POSTN | 0.72 | 0.87 | 0.67 |
| CHI3L1 + PI3 + POSTN | 0.66 | 0.68 | 0.62 |
| CHI3L1 + PI3 + MSR1 up | 0.77 | 0.83 | 0.64 |
| CHI3L1 + PI3 + MSR1 low | 0.97 | ND | 0.95 |
| CHI3L1 + PI3 + PHLDA1 | 0.70 | ND | ND |
| CHI3L1 + PI3 + SERPINB2 | 0.92 | ND | 0.93 |
| CHI3L1 + POSTN + MSR1 up | 0.83 | 0.88 | 0.76 |
| CHI3L1 + POSTN + MSR1 low | 0.97 | ND | 0.94 |
| CHI3L1 + POSTN + PHLDA1 | 0.78 | ND | ND |
| CHI3L1 + POSTN + SERPINB2 | 0.94 | ND | ND |
| IL-10 + PI3 + POSTN | 0.57 | 0.61 | 0.60 |
| IL-8 + PI3 + POSTN | 0.75 | 0.84 | 0.62 |
| PI3 + POSTN + MSR1 up | 0.77 | 0.81 | 0.77 |
| PI3 + POSTN + MSR1 low | 0.97 | ND | 0.96 |
| PI3 + POSTN + PHLDA1 | 0.78 | ND | ND |
| PI3 + POSTN + SERPINB2 | 0.94 | 0.97 | ND |
| (B) Moderate–mild NA compared with the severe group | |||
| Combination of biomarkers | AUC value | ||
| CHI3L1 + IL-10 + PI3 | 0.63 | ||
| CHI3L1 + IL-10 + POSTN | 0.77 | ||
| CHI3L1 + IL-8 + PI3 | 0.88 | ||
| CHI3L1 + IL-8 + POSTN | 0.98 | ||
| CHI3L1 + PI3 + POSTN | 0.76 | ||
| CHI3L1 + PI3 + MSR1 up | 0.78 | ||
| CHI3L1 + PI3 + MSR1 low | 0.68 | ||
| CHI3L1 + PI3 + SERPINB2 | 0.73 | ||
| CHI3L1 + POSTN + MSR1 up | 0.80 | ||
| CHI3L1 + POSTN + MSR1 low | 0.80 | ||
| CHI3L1 + MSR1 up + MSR1 low | 0.68 | ||
| IL-10 + PI3 + POSTN | 0.77 | ||
| IL-8 + PI3 + POSTN | 0.82 | ||
| PI3 + POSTN + MSR1 up | 0.60 | ||
| PI3 + POSTN + MSR1 low | 0.60 | ||
| PI3 + POSTN + SERPINB2 | 0.93 | ||
| PI3 + MSR1 up + MSR1 low | 0.60 | ||
| POSTN + MSR1 up + MSR1 low | 0.62 | ||
In bold are the AUC values greater than 0.75, which are considered good, very good, or excellent tests. C: control group. NA: total nonallergic asthma group. MM: group of subjects with moderate–mild asthma. S: group of subjects with severe asthma. MSR1 low: MSR1’s lower band protein expression. MSR1 up: MSR1’s upper band protein expression.