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. 2018 Jun 21;9:1416. doi: 10.3389/fimmu.2018.01416

Table 5.

Ranking of the best individual and combined proteic biomarkers for each discrimination.

Area under the curve (AUC) (IC 95%) value Threshold
(A) Biomarkers able to discriminate NA patients from C group

  • MSR1 low

  • SERPINB2

  • 0.96 (0.89–1.00)

  • 0.91 (0.72–1.00)

  • 0.148

  • 0.404

  • MSR1 low + MSR1 up

  • CHI3L1 + MSR1 low

  • POSTN + SERPINB2

  • CHI3L1 + SERPINB2

  • POSTN + PHLDA1

  • CHI3L1 + MSR1 up

  • 1

  • 0.97 (0.91–1.00)

  • 0.95 (0.85–1.00)

  • 0.92 (0.77–1.00)

  • 0.82 (0.59–1.00)

  • 0.78 (0.60–0.95)

  • 0.148, 0.208

  • 13,064, 0.148

  • 13,633, 0.404

  • 13,064, 0.404

  • 13,633, 0.011

  • 13,064, 0.208

  • PI3 + POSTN + MSR1 low

  • CHI3L1 + POSTN + MSR1 up

  • PI3 + POSTN + MSR1 up

  • 0.97 (0.90–1.00)

  • 0.83 (0.67–0.98)

  • 0.77 (0.58–0.96)

  • 6,528, 13,633, 0.148

  • 13,064, 13,633, 0.208

  • 6,528, 13,633, 0.208
(B) Biomarkers able to discriminate the moderate/mild NA patients from the C group

  • MSR1 low

  • SERPINB2

  • 1

  • 0.89 (0.66–1.00)

  • 0.148

  • 0.404

  • CHI3L1 + SERPINB2

  • POSTN + SERPINB2

  • IL-8 + POSTN

  • CHI3L1 + MSR1 up

  • POSTN + MSR1 up

  • IL-8 + PI3

  • 0.97 (0.90–1.00)

  • 0.97 (0.90–1.00)

  • 0.87 (0.70–1.00)

  • 0.83 (0.63–1.00)

  • 0.81 (0.58–1.00)

  • 0.76 (0.50–1.00)

  • 13,064, 0.404

  • 15,787, 0.404

  • 677, 15,787

  • 13,064, 0.208

  • 15,787, 0.208

  • 677, 3,074

  • CHI3L1 + IL-8 + POSTN

  • CHI3L1 + IL-8 + PI3

  • 0.87 (0.70–1.00)

  • 0.79 (0.55–1.00)

  • 13,064, 677, 15,787

  • 13,064, 677, 3,074
(C) Biomarkers able to discriminate the severe NA patients from the C group

  • MSR1 low

  • SERPINB2

  • 0.93 (0.80–1.00)

  • 0.93 (0.78–1.00)

  • 0.137

  • 0.359

  • MSR1 low + MSR1 up

  • POSTN + SERPINB2

  • PI3 + MSR1 low

  • CHI3L1 + MSR1 low

  • CHI3L1 + MSR1 up

  • 1

  • 0.97 (0.87–1.00)

  • 0.95 (0.85–1.00)

  • 0.94 (0.83–1.00)

  • 0.76 (0.50–1.00)

  • 0.137, 0.254

  • 13,633, 0.359

  • 6,528, 0.137

  • 14,367, 0.137

  • 14,367, 0.254

  • PI3 + POSTN + MSR1 low

  • CHI3L1 + PI3 + MSR1 low

  • CHI3L1 + IL-8 + PI3

  • PI3 + POSTN + MSR1 up

  • 0.96 (0.88–1.00)

  • 0.95 (0.86–1.00)

  • 0.79 (0.56–1.00)

  • 0.77 (0.54–0.99)

  • 6,528, 13,633, 0.137

  • 14,367, 6,528, 0.137

  • 14,367, 262, 6,528

  • 6,528, 13,633, 0.254
(D) Biomarkers able to discriminate the moderate/mild NA patients from the severe NA group
IL-8 0.76 (0.49–1.00) 841

  • POSTN + SERPINB2

  • IL-8 + PI3

  • IL-8 + POSTN

  • CHI3L1 + POSTN

  • IL-10 + POSTN

  • 0.90 (0.71–1.00)

  • 0.82 (0.58–1.00)

  • 0.78 (0.52–1.00)

  • 0.77 (0.59–0.96)

  • 0.77 (0.43–1.00)

  • 17,419, 0.132

  • 841, 4,845

  • 841, 17,419

  • 18,500, 17,419

  • 105.2, 17,419

  • CHI3L1 + IL-8 + POSTN

  • PI3 + POSTN + SERPINB2

  • CHI3L1 + IL-8 + PI3

  • CHI3L1 + POSTN + MSR1 up

  • CHI3L1 + POSTN + MSR1 low

  • CHI3L1 + PI3 + MSR1 up

  • 0.98 (0.92–1.00)

  • 0.93 (0.78–1.00)

  • 0.88 (0.69–1.00)

  • 0.80 (0.57–1.00)

  • 0.80 (0.57–1.00)

  • 0.78 (0.53–1.00)

  • 18,500, 841, 17,419

  • 4,845, 17,419, 0.132

  • 18,500, 841, 4,845

  • 18,500, 17,419, 0.257

  • 18,500, 17,419, 0.056

  • 18,500, 4,845, 0.257

Summary of the best options for discriminating each condition, obtained from the ROC curve analysis of protein expression from each of the nine biomarkers, alone or in combination. C: control group. NA: nonallergic asthma group. MM: group of subjects with moderate–mild asthma. S: group of subjects with severe asthma. MSR1 low: MSR1’s lower band protein expression. MSR1 up: MSR1’s upper band protein expression. Threshold means the proteic levels of each biomarker able to discriminate each condition, with the AUC indicated. In bold are marked the options with the best statistical power (CI 95% between 0.7 and 1).