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. 2018 Jun 21;9:660. doi: 10.3389/fphar.2018.00660

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Copyright © 2018 Liu, Peng, Liu, Wu, Wang, Wang, Liu, Xia and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of exogenous TWEAK on burn wounds in Fn14-knochout mice. Burn wounds were induced in mice, followed by the treatments of normal saline (NaCl) or TWEAK solution (20 μg/ml). (A) Burn wounds were monitored on day 0, 3, 7, 14, and 21, respectively. (B) The areas of skin wounds were calculated in the three groups. (C) The images of hematoxylin-eosin-stained sections were shown. Arrows indicated renascent epidermis. (D) The epidermal thickness was measured. There were no significant differences in wound area or epidermal thickness between the three groups at the same time point (p > 0.05). Number of mice = 5. Representative images are shown. Bar = 25 μm.