Table 1.
Oncogenic and tumor suppressor miRNAs targeting the components of canonical Wnt signaling pathways in the pathogenesis of HCC.
| miRNAs | Targets in canonical Wnt signaling | Effect | Reference |
|---|---|---|---|
| Targeting Wnt ligands/receptors and associated proteins | |||
| miR-122 | Wnt1 | Tumor suppressor | Xu J. et al., 2012; Ahsani et al., 2017 |
| miR-148a | Wnt1 | Tumor suppressor | Yan et al., 2014 |
| miR-148b | Wnt1 | Tumor suppressor | Zhang J.G. et al., 2015 |
| miR-152 | Wnt1 | Tumor suppressor | Huang et al., 2014 |
| miR-27a | FZD7 | Tumor suppressor | Chen Z. et al., 2013 |
| miR-199a | FZD7 | Tumor suppressor | Song et al., 2014 |
| miR-1269a | LRP6 | Tumor suppressor | Min et al., 2017 |
| miR-202 | LRP6 | Tumor suppressor | Zhang et al., 2014 |
| miR-432 | LRP6 | Tumor suppressor | Jiang et al., 2015 |
| miR-126-3p | LRP6 | Tumor suppressor | Du et al., 2014 |
| miR-610 | LRP6 | Tumor suppressor | Zeng et al., 2014 |
| miR-181a | WIF-1 | Oncogene | Ji et al., 2014 |
| miR-522 | DKK1, sFRP2 | Oncogene | Zhang H. et al., 2016 |
| miR-200b | BMI1 | Tumor suppressor | Wu W.R. et al., 2016 |
| miR-218 | BMI1 | Tumor suppressor | Fu et al., 2015 |
| Targeting β-catenin | |||
| miR-214 | β-catenin | Tumor suppressor | Wang et al., 2012; Xia et al., 2012 |
| miR-200a | β-catenin | Tumor suppressor | Liu et al., 2013 |
| miR-320a | β-catenin | Tumor suppressor | Lu et al., 2017 |
| miR-338-3p | β-catenin | Tumor suppressor | Zhang T. et al., 2016 |
| miR-33a | β-catenin | Tumor suppressor | Fang et al., 2013 |
| miR-153 | WWOX (β-catenin inhibitor) | Oncogene | Hua et al., 2015 |
| miRNAs | Target in Wnt signaling | Effect | Reference |
| Targeting β-catenin interacting proteins | |||
| miR-9 | E-cadherin (CDH1) | Oncogene | Tan et al., 2010; Drakaki et al., 2015 |
| miR-106b | APC | Oncogene | Shen et al., 2013 |
| miR-155 | APC | Oncogene, | Zhang et al., 2012 |
| miR-107 | AXIN2 | Oncogene | Zhang J.J. et al., 2015 |
| miR-1246 | AXIN2, GSK3β | Oncogene | Chai et al., 2016 |
| miR-920 | β-TRCP | Tumor suppressor | Chen et al., 2010 |
| Targeting transcription factors in canonical Wnt pathway | |||
| miR-139 | TCF-4 | Tumor suppressor | Gu et al., 2014 |
| miR-30-5p | BCL9 | tumor suppressor | Zhao et al., 2014 |
| miR-101 | NLK2 | Tumor suppressor | Shen et al., 2014 |
| miR-181 | NLK | Oncogene | Ji et al., 2009 |
| miR-20a-5p | RUNX3 | Oncogene | Chen et al., 2016 |
| miR-130a | RUNX3 | Oncogene | Xu N. et al., 2012 |
| miR-129-2 | SOX4 | Tumor suppressor | Chen X. et al., 2013 |
| miR-935, miR-24, miR-184 | SOX7 | Oncogene | Ma et al., 2014; Wu et al., 2014; Liu et al., 2017 |
| miR-221 | HDAC6 | Oncogene | Bae et al., 2015 |
| targeting β-catenin responsive genes | |||
| miR-29b | MMP-2 | Tumor suppressor | Fang et al., 2011 |
| miR-451 | MMP-9 | Tumor suppressor | Arii et al., 1996 |
| miR-199a | MMP-9 | Tumor suppressor | Zhang et al., 2013 |
| miR-451 | c-Myc | Tumor suppressor | Huang et al., 2015 |
| miR-34a | c-Myc | Tumor suppressor | Xu et al., 2015 |
| let-7a | c-Myc | Tumor suppressor | Deng et al., 2016 |
| miR-199a-3p | CD44 | Tumor suppressor | Henry et al., 2010 |
| miR-101 | COX2 | Tumor suppressor | Zheng et al., 2015 |
| miR-19a | cyclin D1 | Tumor suppressor | Zhang Y. et al., 2015 |
| miR-20a | cyclin D1 | Tumor suppressor | Karimkhanloo et al., 2017 |
| miR-384 | IRS1- cyclin D1 | Tumor suppressor | Lai et al., 2016 |