FIGURE 1.

Effect of trimebutine on glioma/glioblastoma cell viability. IC50 values in either normal human astroglia HEB cell line (A) or the three glioma/glioblastoma cell lines (B). SHG44 and U251 human glioma and U-87 MG human glioblastoma cells were treated with various concentrations of trimebutine for 24 (C), 48 (D), and 72 h (E). MTT assay was used to assess cell viability. The data are presented as the means ± SEM from 3 independent experiments. ^∗P < 0.05 and ^∗∗P < 0.01 vs. vehicle control (one-way ANOVA with Tukey’s post hoc test).