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Reasons for trial discontinuation
| Reason | n | % |
|---|---|---|
| None reported or unclear | 51 | 40 |
| Informative termination∗ | 34 | 27 |
| Patient accrual | 17 | 13 |
| Company/business decision | 11 | 9 |
| Principal investigator left | 5 | 4 |
| Conduct problems† | 4 | 3 |
| Regulatory issue‡ | 3 | 2 |
| Funding issue | 2 | 2 |
Changes in standard of care and safety or efficacy findings.
Technical/logistical issues.
Issues with institutional review board or other regulatory body.
