Table 3. Associations between genetic polymorphisms and AD severity.
| SNP | (Nearby) gene | Minor allele | MAF | AD severity | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control (n = 460) | AD cases | Control vs Moderate | Control vs Severe | Moderate vs Severe | |||||||
| Moderate (n = 264) | Severe (n = 161) | P | Pcor. | P | Pcor. | P | Pcor. | ||||
| rs6682925 | IL23R | C | 0.403 | 0.407 | 0.453 | 0.33 | - | 0.19 | - | 0.21 | - |
| rs7622183 | IL5RA | T | 0.517 | 0.471 | 0.451 | 0.05 | - | 0.15 | - | 0.66 | - |
| rs17454584 | (IL2) | G | 0.101 | 0.128 | 0.124 | 0.02 | NS | 0.07 | - | 0.58 | - |
| rs17389644 | (IL21) | A | 0.103 | 0.126 | 0.129 | 0.02 | NS | 0.03 | NS | 0.81 | - |
| rs10214237 | (IL7R) | C | 0.179 | 0.183 | 0.156 | 0.98 | - | 0.99 | - | 0.26 | - |
| rs13361382 | TMEM232 | A | 0.106 | 0.118 | 0.137 | 0.97 | - | 0.48 | - | 0.23 | - |
| rs6871536 | RAD50/TH2LCRR | C | 0.185 | 0.198 | 0.232 | 0.39 | - | 0.26 | - | 0.34 | - |
| rs2569190 | CD14/TMCO6 | G | 0.384 | 0.374 | 0.346 | 0.90 | - | 0.38 | - | 0.52 | - |
| rs11741861 | IRGM/ZNF300 | G | 0.365 | 0.362 | 0.399 | 0.60 | - | 0.03 | 0.45 | - | |
| rs4713555 | (HLA-DRB1/HLA-DQA1) | T | 0.281 | 0.322 | 0.331 | 0.12 | - | 0.18 | - | 0.90 | - |
| rs2275913 | IL17A | A | 0.431 | 0.447 | 0.436 | 0.98 | - | 0.83 | - | 0.87 | - |
| rs9357733 | EFHC1 | G | 0.338 | 0.322 | 0.287 | 0.50 | - | 0.52 | - | 0.32 | - |
| rs4271002 | NAT2 | C | 0.223 | 0.232 | 0.203 | 0.68 | - | 0.41 | - | 0.28 | - |
| rs6473227 | (ZBTB10) | A | 0.427 | 0.367 | 0.343 | 0.14 | - | 0.004 | NS | 0.58 | - |
| rs4246905 | TNFSF15 | T | 0.330 | 0.324 | 0.338 | 0.60 | - | 0.77 | - | 0.54 | - |
| rs2212434 | (EMSY) | C | 0.516 | 0.500 | 0.430 | 0.29 | - | 0.03 | NS | 0.06 | - |
| rs2143950 | (PPP2R3C) | T | 0.353 | 0.405 | 0.399 | 0.01 | NS | 0.47 | - | 0.86 | - |
P value of logistic analysis under additive model by adjusting age and sex as covariates. Bold values indicate the statistical significance of P<0.05. Pcor. value corrected for multiple testing (effective number of correction=15.98) using the SNPSpD program.
AD, atopic dermatitis; SNP, single nucleotide polymorphism; MAF, minor allele frequency; NS, not significant.