Table 4. Associations of genetic polymorphisms with SCORAD and total IgE.
| SNP | SCORAD | Total IgE | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Score | Genetic model | Score | Genetic model | |||||||||||||||
| Additive | Dominant | Recessive | Additive | Dominant | Recessive | |||||||||||||
| M/M (No.) | M/m (No.) | m/m (No.) | P | Pcor. | P | Pcor. | P | Pcor. | M/M (No.) | M/m (No.) | m/m (No.) | P | Pcor. | P | Pcor. | P | Pcor. | |
| rs6682925 | 71.03 ± 9.02 (62) | 69.77 ± 7.66 (83) | 67.00 ± 10.34 (42) | 0.21 | - | 0.34 | - | 0.26 | - | 715.1 ± 60.7 (139) | 612.9 ± 45.1 (185) | 624.7 ± 69.8 (80) | 0.21 | - | 0.16 | - | 0.55 | - |
| rs7622183 | 67.78 ± 9.14 (55) | 68.55 ± 7.39 (86) | 73.79 ± 10.88 (46) | 0.14 | - | 0.42 | - | 0.10 | - | 707.9 ± 64.6 (120) | 620.8 ± 44.3 (196) | 665.4 ± 70.5 (89) | 0.52 | - | 0.87 | - | 0.19 | - |
| rs17454584 | 68.77 ± 5.88 (137) | 71.99 ± 9.98 (52) | - (0) | 0.21 | - | 0.21 | - | - | - | 610.6 ± 34.6 (312) | 702.5 ± 71.7 (96) | 2,439.5 ± 1,219.8 (4) | 0.28 | - | 0.55 | - | 0.01 | NS |
| rs17389644 | 68.77 ± 5.88 (137) | 71.67 ± 10.04 (51) | - (0) | 0.26 | - | 0.26 | - | - | - | 608.1 ± 34.7 (308) | 695.0 ± 70.9 (96) | 2,439.5 ± 1,219.8 (4) | 0.30 | - | 0.58 | - | 0.01 | NS |
| rs10214237 | 70.36 ± 6.17 (130) | 67.66 ± 9.29 (53) | 87.00 ± 50.23 (3) | 0.91 | - | 0.56 | - | 0.09 | - | 610.9 ± 37.0 (273) | 759.7 ± 69.4 (120) | 332.6 ± 105.2 (10) | 0.94 | - | 0.69 | - | 0.34 | - |
| rs13361382 | 67.81 ± 5.71 (141) | 76.52 ± 12.10 (40) | 90.40 (1) | 0.003 | 0.04 | 0.004 | NS | 0.22 | - | 565.3 ± 32.9 (295) | 769.8 ± 81.1 (90) | 821.5 ± 410.8 (4) | 0.13 | - | 0.13 | - | 0.64 | - |
| rs6871536 | 69.20 ± 6.45 (115) | 68.77 ± 8.88 (60) | 82.81 ± 26.19 (10) | 0.21 | - | 0.62 | - | 0.03 | NS | 601.2 ± 38.3 (247) | 718.6 ± 63.0 (130) | 532.0 ± 125.4 (18) | 0.39 | - | 0.22 | - | 0.63 | - |
| rs2569190 | 69.85 ± 7.96 (77) | 66.86 ± 7.43 (81) | 77.01 ± 15.10 (26) | 0.35 | - | 0.79 | - | 0.02 | - | 568.0 ± 44.5 (163) | 792.4 ± 58.1 (186) | 427.6 ± 58.2 (54) | 0.75 | - | 0.57 | - | 0.14 | - |
| rs11741861 | 73.50 ± 8.07 (83) | 65.63 ± 7.29 (81) | 69.97 ± 13.99 (25) | 0.06 | - | 0.009 | NS | 0.96 | - | 552.7 ± 43.2 (164) | 736.8 ± 54.3 (184) | 654.9 ± 82.5 (63) | 0.98 | - | 0.68 | - | 0.53 | - |
| rs4713555 | 70.49 ± 8.03 (77) | 69.66 ± 7.51 (86) | 68.51 ± 14.29 (23) | 0.61 | - | 0.66 | - | 0.70 | - | 679.7 ± 50.4 (182) | 532.6 ± 39.6 (181) | 1,081.6 ± 168.9 (41) | 0.08 | - | 0.95 | - | <0.0001 | <0.001 |
| rs2275913 | 64.62 ± 8.79 (54) | 72.71 ± 7.71 (89) | 71.47 ± 10.90 (43) | 0.06 | - | 0.01 | NS | 0.66 | - | 569.9 ± 51.0 (125) | 700.6 ± 50.4 (193) | 600.9 ± 67.2 (80) | 0.81 | - | 0.91 | - | 0.59 | - |
| rs9357733 | 69.87 ± 6.99 (100) | 71.53 ± 8.67 (68) | 63.57 ± 14.58 (19) | 0.47 | - | 0.99 | - | 0.11 | - | 615.4 ± 43.6 (199) | 742.2 ± 59.4 (156) | 447.1 ± 65.9 (46) | 0.50 | - | 0.91 | - | 0.20 | - |
| rs4271002 | 68.84 ± 6.62 (108) | 70.78 ± 8.28 (73) | 70.70 ± 26.72 (7) | 0.43 | - | 0.40 | - | 0.87 | - | 683.7 ± 44.1 (240) | 604.1 ± 48.8 (153) | 482.8 ± 133.9 (13) | 0.22 | - | 0.23 | - | 0.59 | - |
| rs6473227 | 70.60 ± 8.38 (71) | 68.74 ± 7.02 (96) | 70.59 ± 15.40 (21) | 0.74 | - | 0.59 | - | 0.89 | - | 643.2 ± 49.2 (171) | 701.5 ± 51.3 (187) | 503.5 ± 69.8 (52) | 0.98 | - | 0.49 | - | 0.33 | - |
| rs4246905 | 69.24 ± 7.51 (85) | 69.53 ± 7.59 (84) | 74.53 ± 17.57 (18) | 0.35 | - | 0.59 | - | 0.24 | - | 704.1 ± 52.2 (182) | 620.3 ± 46.4 (179) | 420.9 ± 64.2 (43) | 0.40 | - | 0.78 | - | 0.18 | - |
| rs2212434 | 74.00 ± 11.03 (45) | 67.88 ± 6.93 (96) | 69.18 ± 10.55 (43) | 0.19 | - | 0.07 | - | 0.77 | - | 742.2 ± 72.8 (104) | 617.4 ± 42.8 (208) | 590.8 ± 63.7 (86) | 0.47 | - | 0.64 | - | 0.48 | - |
| rs2143950 | 70.24 ± 8.71 (65) | 68.87 ± 7.22 (91) | 70.21 ± 12.41 (30) | 0.87 | - | 0.73 | - | 0.89 | - | 599.2 ± 50.1 (143) | 647.1 ± 45.9 (199) | 812.5 ± 102.4 (63) | 0.22 | - | 0.38 | - | 0.24 | - |
P value of linear regression analysis under additive model by adjusting age and sex as covariates. Pcor. value corrected for multiple testing (effective number of correction=15.98) using the SNPSpD program. M/M, M/m, and m/m indicate the homozygote of the major allele, heterozygote, and homozygote of the minor allele, respectively. Bold values indicate the statistical significance of P<0.05.
AD, atopic dermatitis; SCORAD, SCORing AD; IgE, immunoglobulin E; NS, not significant; n, number of subjects.