TABLE 1.
Antifungal activity of NVN1000 and ketoconazole against a panel of fungal isolates
| Fungal species and strain | NVN1000 MIC (μg NO/ml) | Ketoconazole MIC (μg/ml) |
|---|---|---|
| Trichophyton rubrum | ||
| NCPF 0113 | 75.5 | >32.0 |
| NCPF 0118 | 302 | <0.063 |
| NCPF 0295 | 604 | >32.0 |
| NCPF 5025 | 302 | >32.0 |
| ATCC MYA-4438 | 302 | >32.0 |
| ATCC 10218 | 75.5 | <0.063 |
| ATCC 22402 | 151 | <0.063 |
| ATCC 28188 | 604 | 0.125 |
| ATCC 44697 | 302 | >32.0 |
| Trichophyton mentagrophytes | ||
| NCPF 0224 | 604 | 0.25 |
| NCPF 5024 | 1,208 | 0.5 |
| ATCC 9533 | 151 | 1.0 |
| ATCC 18749 | 75.5 | 0.125 |
| ATCC 28939 | 75.5 | 1.0 |
| Epidermophyton floccosum | ||
| NCPF 5011 | 1,208 | >32.0 |
| NCPF 5012 | 302 | >32.0 |
| ATCC 38826 | 151 | 4.0 |
| ATCC 44685 | 604 | 0.125 |
| ATCC 52061 | 604 | 1.0 |
| ATCC 52063 | 302 | >32.0 |
| ATCC 52066 | 604 | >32.0 |
| Fusarium species | ||
| Fusarium keratoplasticum ATCC 36031 | 604 | >32.0 |
| Fusarium oxysporum ATCC 62705 | 302 | >32.0 |
| Fusarium solani ATCC 56480 | 604 | >32.0 |
| Malassezia furfur | ||
| NCPF 3349 | 75.5 | >32.0 |
| NCPF 8211 | 151 | 16.0 |
| ATCC 14521 | 151 | >32.0 |
| Candida albicans | ||
| ATCC 10231 | 151 | <0.063 |
| ATCC 58716 | 151 | 16.0 |
| ATCC 96901 | 151 | >32.0 |
| BLSI 112613Ca1 | 151 | >32.0 |
| BLSI 112613Ca2 | 151 | >32.0 |
| Candida species | ||
| Candida lusitaniae ATCC 200950 | 151 | <0.063 |
| Candida tropicalis NCPF 8760 | 1,208 | 32.0 |