TABLE 3.
Prior distributions for population geometric means and variances of the PK model parametersa
| Parameter (units) |
eμ |
ω2 | |
|---|---|---|---|
| LN(log(GM), log(GSD)) | Truncation bounds | ||
| ED50 (mg) | LN(6.21, 0.18) | [90, 3,000] | HN(0.2) |
| τF (h) | LN(6.40, 0.47) | [60, 6,000] | HN(0.2) |
| ka (1/h) | LN(−0.2, 0.18) | [0.1, 4] | HN(0.2) |
| VC (liters) | LN(4.55, 0.18) | [20, 500] | HN(0.2) |
| CLC (liters/h) | LN(1.22, 0.18) | [0.6, 20] | HN(0.2) |
a
eμ, geometric mean; ω2, variance; LN(log(GM), log(GSD)), lognormal distribution(log geometric mean, log geometric standard deviation); HN(SD), half-normal distribution (standard deviation).