TABLE 7.
Summaries of the marginal posterior population geometric means and CVs of the PK model parametersa
| Parameter (units) |
eμ |
CV |
||||
|---|---|---|---|---|---|---|
| Mode | Mean (SD) | 2.5th percentile, 97.5th percentile | Mode | Mean (SD) | 2.5th percentile, 97.5th percentile | |
| ED50 (mg) | 440 | 450 (52) | 360, 560 | 0.71 | 0.74 (0.092) | 0.57, 0.93 |
| τF (h) | 1,100 | 1,200 (190) | 880, 1600 | 0.76 | 0.78 (0.12) | 0.55, 1.00 |
| ka (1/h) | 0.3 | 0.3 (0.027) | 0.27, 0.34 | 0.63 | 0.66 (0.07) | 0.53, 0.81 |
| VC (liters) | 130 | 130 (5.3) | 120, 140 | 0.15 | 0.17 (0.043) | 0.073, 0.24 |
| CLC (liters/h) | 4.8 | 4.8 (0.22) | 4.4, 5.3 | 0.31 | 0.32 (0.03) | 0.26, 0.38 |
a
eμ, geometric mean; CV, coefficient of variation.