TABLE 8.
Summaries of marginal posterior individual parameter means for PK model parameters and comparison of values between male and female patients
| Parameter | Mean (SD) values for: |
P valuea | ||
|---|---|---|---|---|
| Total | Male | Female | ||
| ED50 (mg) | 554 (265) | 567 (266) | 539 (265) | 0.6 |
| τF (h) | 1,487 (468) | 1,410 (486) | 1,570 (435) | 0.06 |
| ka (1/h) | 0.34 (0.21) | 0.33 (0.18) | 0.36 (0.24) | 0.4 |
| VC (liters) | 128 (11) | 124 (9.79) | 132 (11.3) | 0.0002 |
| CLC (liters /h) | 5.09 (1.35) | 5.36 (1.21) | 4.79 (1.44) | 0.02 |
a
Welch's t test comparison between males and females.