TABLE 1.
Organ CFU counts before and after treatment with experimental regimens
| Time of infection or treatmenta | Mean no. of log CFU per lung ± SD |
Mean no. of log CFU per spleen ± SD |
||||||
|---|---|---|---|---|---|---|---|---|
| Control | RHZE regimen | RHZM regimen | RMZE regimen | Control | RHZE regimen | RHZM regimen | RMZE regimen | |
| Day 0 | 4.80 ± 0.14 | 5.29 ± 0.03 | ||||||
| Day 21 | 7.54 ± 0.03 | 6.99 ± 0.06 | ||||||
| 2 wk | 6.09 ± 0.03 | 5.92 ± 0.14 | 5.70 ± 0.12 | 5.43 ± 0.08 | 5.54 ± 0.12 | 4.77 ± 0.10 | ||
| 4 wk | 4.80 ± 0.07 | 4.52 ± 0.28 | 3.61 ± 0.16 | 4.05 ± 0.02 | 4.49 ± 0.08 | 3.31 ± 0.21 | ||
| 6 wk | 4.08 ± 0.11 | 4.00 ± 0.09 | 2.53 ± 0.29 | 3.49 ± 0.16 | 3.81 ± 0.06 | 2.27 ± 0.20 | ||
| 8 wk | 3.00 ± 0 | 3.25 ± 0.48 | 2.00 ± 0 | 2.44 ± 0.22 | 3.24 ± 0.13 | 1.57 ± 0.20 | ||
| 11 wkb | 2.00 ± 0 | 2.00 ± 0 | 0 | 1.19 ± 0.29 | 2.00 ± 0 | 0 | ||
| 14 wkb | 0 | 0 | 0 | 0 | 0 | 0 | ||
a
Day 0 and day 21 represent 2 h and 21 days postinfection, respectively. Times in weeks represent times posttreatment.
b
CFU counts were derived from one-third of the tissue homogenate, and the limit of detection was 3 CFU/organ.