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Comparison of the predicted (white bars) and observed (gray bars) AUC ratio plus standard deviations for the two victim drugs with intrinsic inhibitory (ritonavir) and inducing (etravirine) properties administered together with the three CYP3A inhibitors cimetidine (InR3A, 0.256 [0.049, 0.570]), fluconazole (InR3A, 0.700 [0.403, 0.893]), and ketoconazole (InR3A, 0.943 [0.823, 1.0]). The red line represents the calculated value without using Monte Carlo predictions.
