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DDI magnitudes between tyrosine kinase inhibitors with increasing DPI3A and the potent CYP3A inhibitor ritonavir predicted by running 10,000 Monte Carlo simulations. The solid red line shows the calculated value without using Monte Carlo predictions. The solid line, the dotted line, and the dashed line represent the 1.25-fold, 2.0-fold, and 5.0-fold increases in the AUC ratio according to the FDA classification of DDI magnitudes (29).
