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EC50 for each variant measured in the H77S.3/GLuc2A backbone
| Variant | EC50 (nM) | FC |
|---|---|---|
| Wild type | 6 | 1 |
| Q80K | 112 | 19 |
| Q80R | 102 | 17 |
| R155K | 259 | 43 |
| R155T | 85 | 14 |
| R155Q | 5 | 0.8 |
| R155G | 74 | 12 |
| R155W | 544 | 90.7 |
| D168A | 5,755 | 959 |
| D168V | 8,070 | 1,345 |
| Q80K+R155K | 2,879 | 480 |
| Q80R+R155K | 2,709 | 452 |
| Q80R+R155Q | 356 | 59 |
| Q80R+R155G | 2,677 | 446 |
| Q80R+R155T | 1,035 | 173 |
| Q80R+R155W | 4,110 | 685 |
