TABLE 1.
MICs of all tested antibiotics for each Borrelia strain
| Antimicrobial agent and MIC type | MIC range (mg/liter)a |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| PKo | HS1 | HT31 | Izh-4 | Izh-5 | Izh-14 | Izh-16 | Yek-1 | Yek-6 | |
| Amoxicillin | |||||||||
| MICc | 4 | 8 | 8 | 8 | 16 | 8 | 8 | 16 | 16 |
| MICm | 4 | 8–16b | 16b | 8–16b | 16–32b | 8b | 8–16b | 16b | 16b |
| Doxycycline | |||||||||
| MICc | 4 | 0.25 | 0.125 | 0.25 | 0.125 | 0.0625 | 0.125 | 0.125 | 0.125 |
| MICm | 4 | 0.25c | 0.0625c | 0.25c | 0.125–0.25c | 0.125–0.25c | 0.25c | 0.25c | 0.25c |
| Ceftriaxone | |||||||||
| MICc | 0.125 | 0.06 | 0.03 | 0.06 | 0.06 | 0.03 | 0.03 | 0.06 | 0.06 |
| MICm | 0.125 | 0.125 | 0.03 | 0.03–0.06 | 0.06–0.125 | 0.03–0.06 | 0.03 | 0.03–0.06 | 0.03–0.06 |
| Azithromycin | |||||||||
| MICc | 0.0032 | 0.0032 | NR | 0.0016 | 0.0016 | 0.0016 | 0.0016 | 0.0032 | 0.0032 |
| MICm | 0.0064 | 0.0064 | 0.0032–0.0064 | 0.0016 | 0.0016–0.0032 | 0.0016 | 0.0016–0.0032 | 0.0032 | 0.0032 |
a
MIC ranges are the results of tests conducted in quadruplicate. PKo, B. afzelii (B. burgdorferi sensu lato control); HS1, B. hermsii (RF Borrelia control); HT31, B. miyamotoi laboratory strain (B. miyamotoi control); Izh-4, Izh-5, Izh-14, Izh-16, Yek-1, and Yek-6 (B. miyamotoi clinical isolates). NR, not reached.
b
Significantly (P < 0.05) higher from the amoxicillin MICm found for PKo.
c
Significantly (P < 0.05) lower from the doxycycline MICm found for PKo.