TABLE 1.
Antimicrobial activity of murepavadin and comparator polymyxin agents tested against P. aeruginosa isolates from the United States, Europe, and China
| Organism and subset (no. of isolates) | No. (cumulative %) of isolates at MIC (mg/liter) of: |
MIC50 | MIC90 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |||
| Pseudomonas aeruginosa | |||||||||||||||
| Murepavadin (1,219) | 0 (0.0) | 25 (2.1) | 92 (9.6) | 983 (90.2) | 93 (97.9) | 15 (99.1) | 5 (99.5) | 2 (99.7) | 0 (99.7) | 2 (99.8) | 1 (99.9) | 0 (99.9) | 1 (100.) | 0.12 | 0.12 |
| Colistin (1,219) | 0 (0.0) | 1 (0.1) | 22 (1.9) | 170 (15.8) | 927 (91.9) | 86 (98.9) | 13 (100.0) | 1 | 1 | ||||||
| Polymyxin B (1,219) | 0 (0.0) | 1 (0.1) | 26 (2.2) | 643 (55.0) | 541 (99.3) | 8 (100.0) | 0.5 | 1 | |||||||
| MDR P. aeruginosa | |||||||||||||||
| Murepavadin (300) | 0 (0.0) | 3 (1.0) | 9 | 216 (76.0) | 55 (94.3) | 10 (97.7) | 3 (98.7) | 1 (99.0) | 0 (99.0) | 1 (99.3) | 1 (99.7) | 0 (99.7) | 1 (100.0) | 0.12 | 0.25 |
| Colistin (300) | 0 (0.0) | 8 (2.7) | 42 (16.7) | 232 (94.0) | 1599.0 | 3 (100.0) | 1 | 1 | |||||||
| Polymyxin B (300) | 0 (0.0) | 8 (2.7) | 142 (50.0) | 148 (99.3) | 2 (100.0) | 0.5 | 1 | ||||||||
| XDR P. aeruginosa | |||||||||||||||
| Murepavadin (167) | 0 (0.0) | 1 (0.6) | 5 (3.6) | 120 (75.4) | 32 (94.6) | 4 (97.0) | 2 (98.2) | 1 (98.8) | 0 (98.8) | 1 (99.4) | 0 (99.4) | 0 (99.4) | 1 (100.0) | 0.12 | 0.25 |
| Colistin (167) | 0 (0.0) | 4 (2.4) | 19 (13.8) | 139 (97.0) | 4 (99.4) | 1 (100.0) | 1 | 1 | |||||||
| Polymyxin B (167) | 0 (0.0) | 3 (1.8) | 77 (47.9) | 85 (98.8) | 2 (100.0) | 1 | 1 | ||||||||