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. 2018 Jun 26;62(7):e00311-18. doi: 10.1128/AAC.00311-18

TABLE 2.

Activity of murepavadin and comparator antimicrobial agents tested against P. aeruginosa

Antimicrobial agent (no. of isolates) MIC50 CLSIa
EUCASTa
MIC90 %S %R %S %R
All (1,219)
    Murepavadin 0.12 0.12
    Colistin 1 1 98.9 1.1 98.9 1.1
    Polymyxin B 0.5 1 100.0 0.0
    Amikacin 4 16 90.6 6.1 87.4 9.4
    Aztreonam 8 32 69.1 15.2 4.2 15.2
    Cefepime 2 16 79.8 8.8 79.8 20.2
    Ceftazidime 2 >32 79.1 16.9 79.1 20.9
    Ciprofloxacin 0.12 >8 77.4 18.1 73.0 27.0
    Meropenem 0.5 16 74.7 18.2 74.7 11.6
    Piperacillin-tazobactam 4 128 73.9 13.3 73.9 26.1
    Tobramycin 0.5 >16 87.9 11.3 87.9 12.1
MDR (300)
    Murepavadin 0.12 0.25
    Colistin 1 1 99.0 1.0 99.0 1.0
    Polymyxin B 0.5 1 100.0 0.0
    Amikacin 8 >64 66.0 22.3 59.0 34.0
    Aztreonam 16 64 24.0 45.0 2.7 45.0
    Cefepime 16 >32 32.3 34.0 32.3 67.7
    Ceftazidime 32 >32 32.7 55.0 32.7 67.3
    Ciprofloxacin 8 >8 25.3 64.3 21.3 78.7
    Meropenem 8 >16 16.3 68.3 16.3 45.3
    Piperacillin-tazobactam 64 >128 21.3 45.3 21.3 78.7
    Tobramycin 2 >16 56.0 42.0 56.0 44.0
XDR (167)
    Murepavadin 0.12 0.25
    Colistin 1 1 99.4 0.6 99.4 0.6
    Polymyxin B 1 1 100.0 0.0
    Amikacin 32 >64 48.5 34.1 43.7 51.5
    Aztreonam 32 >64 14.4 51.5 0.6 51.5
    Cefepime 16 >32 12.6 49.1 12.6 87.4
    Ceftazidime >32 >32 13.8 73.1 13.8 86.2
    Ciprofloxacin >8 >8 9.0 85.0 5.4 94.6
    Meropenem 16 >16 1.8 86.8 1.8 67.7
    Piperacillin-tazobactam 128 >128 5.4 57.5 5.4 94.6
    Tobramycin >16 >16 35.3 62.9 35.3 64.7
United States (417)
    Murepavadin 0.12 0.12
    Colistin 1 1 99.3 0.7 99.3 0.7
    Polymyxin B 0.5 1 100.0 0.0
    Amikacin 4 8 95.7 2.4 91.6 4.3
    Aztreonam 8 32 71.5 13.7 5.3 13.7
    Cefepime 2 16 84.4 6.2 84.4 15.6
    Ceftazidime 2 32 84.2 10.8 84.2 15.8
    Ciprofloxacin 0.12 8 81.1 14.4 77.7 22.3
    Meropenem 0.5 8 80.6 13.9 80.6 6.5
    Piperacillin-tazobactam 4 64 79.4 8.6 79.4 20.6
    Tobramycin 0.5 2 92.6 7.0 92.6 7.4
Europe (491)
    Murepavadin 0.12 0.12
    Colistin 1 1 99.0 1.0 99.0 1.0
    Polymyxin B 0.5 1 100.0 0.0
    Amikacin 4 32 86.8 7.3 84.3 13.2
    Aztreonam 4 32 69.7 12.0 3.5 12.0
    Cefepime 2 16 79.4 9.0 79.4 20.6
    Ceftazidime 2 >32 77.8 18.3 77.8 22.2
    Ciprofloxacin 0.12 >8 75.8 21.2 70.7 29.3
    Meropenem 0.5 16 72.9 19.3 72.9 14.5
    Piperacillin-tazobactam 4 128 74.1 13.4 74.1 25.9
    Tobramycin 0.5 >16 86.8 12.8 86.8 13.2
China (311)
    Murepavadin 0.12 0.12
    Colistin 1 2 98.4 1.6 98.4 1.6
    Polymyxin B 1 1 100.0 0.0
    Amikacin 4 16 90.0 9.0 86.5 10.0
    Aztreonam 8 32 65.0 22.2 3.9 22.2
    Cefepime 4 32 74.3 11.9 74.3 25.7
    Ceftazidime 4 >32 74.3 22.8 74.3 25.7
    Ciprofloxacin 0.25 8 74.9 18.3 70.4 29.6
    Meropenem 1 16 69.8 22.2 69.8 13.8
    Piperacillin-tazobactam 8 >128 66.2 19.3 66.2 33.8
    Tobramycin 0.5 >16 83.6 14.8 83.6 16.4
a

Criteria as published by CLSI and EUCAST (17, 18). S, susceptible; R, resistant.