TABLE 2.
Antimicrobial agent (no. of isolates) | MIC50 | CLSIa |
EUCASTa |
|||
---|---|---|---|---|---|---|
MIC90 | %S | %R | %S | %R | ||
All (1,219) | ||||||
Murepavadin | 0.12 | 0.12 | ||||
Colistin | 1 | 1 | 98.9 | 1.1 | 98.9 | 1.1 |
Polymyxin B | 0.5 | 1 | 100.0 | 0.0 | ||
Amikacin | 4 | 16 | 90.6 | 6.1 | 87.4 | 9.4 |
Aztreonam | 8 | 32 | 69.1 | 15.2 | 4.2 | 15.2 |
Cefepime | 2 | 16 | 79.8 | 8.8 | 79.8 | 20.2 |
Ceftazidime | 2 | >32 | 79.1 | 16.9 | 79.1 | 20.9 |
Ciprofloxacin | 0.12 | >8 | 77.4 | 18.1 | 73.0 | 27.0 |
Meropenem | 0.5 | 16 | 74.7 | 18.2 | 74.7 | 11.6 |
Piperacillin-tazobactam | 4 | 128 | 73.9 | 13.3 | 73.9 | 26.1 |
Tobramycin | 0.5 | >16 | 87.9 | 11.3 | 87.9 | 12.1 |
MDR (300) | ||||||
Murepavadin | 0.12 | 0.25 | ||||
Colistin | 1 | 1 | 99.0 | 1.0 | 99.0 | 1.0 |
Polymyxin B | 0.5 | 1 | 100.0 | 0.0 | ||
Amikacin | 8 | >64 | 66.0 | 22.3 | 59.0 | 34.0 |
Aztreonam | 16 | 64 | 24.0 | 45.0 | 2.7 | 45.0 |
Cefepime | 16 | >32 | 32.3 | 34.0 | 32.3 | 67.7 |
Ceftazidime | 32 | >32 | 32.7 | 55.0 | 32.7 | 67.3 |
Ciprofloxacin | 8 | >8 | 25.3 | 64.3 | 21.3 | 78.7 |
Meropenem | 8 | >16 | 16.3 | 68.3 | 16.3 | 45.3 |
Piperacillin-tazobactam | 64 | >128 | 21.3 | 45.3 | 21.3 | 78.7 |
Tobramycin | 2 | >16 | 56.0 | 42.0 | 56.0 | 44.0 |
XDR (167) | ||||||
Murepavadin | 0.12 | 0.25 | ||||
Colistin | 1 | 1 | 99.4 | 0.6 | 99.4 | 0.6 |
Polymyxin B | 1 | 1 | 100.0 | 0.0 | ||
Amikacin | 32 | >64 | 48.5 | 34.1 | 43.7 | 51.5 |
Aztreonam | 32 | >64 | 14.4 | 51.5 | 0.6 | 51.5 |
Cefepime | 16 | >32 | 12.6 | 49.1 | 12.6 | 87.4 |
Ceftazidime | >32 | >32 | 13.8 | 73.1 | 13.8 | 86.2 |
Ciprofloxacin | >8 | >8 | 9.0 | 85.0 | 5.4 | 94.6 |
Meropenem | 16 | >16 | 1.8 | 86.8 | 1.8 | 67.7 |
Piperacillin-tazobactam | 128 | >128 | 5.4 | 57.5 | 5.4 | 94.6 |
Tobramycin | >16 | >16 | 35.3 | 62.9 | 35.3 | 64.7 |
United States (417) | ||||||
Murepavadin | 0.12 | 0.12 | ||||
Colistin | 1 | 1 | 99.3 | 0.7 | 99.3 | 0.7 |
Polymyxin B | 0.5 | 1 | 100.0 | 0.0 | ||
Amikacin | 4 | 8 | 95.7 | 2.4 | 91.6 | 4.3 |
Aztreonam | 8 | 32 | 71.5 | 13.7 | 5.3 | 13.7 |
Cefepime | 2 | 16 | 84.4 | 6.2 | 84.4 | 15.6 |
Ceftazidime | 2 | 32 | 84.2 | 10.8 | 84.2 | 15.8 |
Ciprofloxacin | 0.12 | 8 | 81.1 | 14.4 | 77.7 | 22.3 |
Meropenem | 0.5 | 8 | 80.6 | 13.9 | 80.6 | 6.5 |
Piperacillin-tazobactam | 4 | 64 | 79.4 | 8.6 | 79.4 | 20.6 |
Tobramycin | 0.5 | 2 | 92.6 | 7.0 | 92.6 | 7.4 |
Europe (491) | ||||||
Murepavadin | 0.12 | 0.12 | ||||
Colistin | 1 | 1 | 99.0 | 1.0 | 99.0 | 1.0 |
Polymyxin B | 0.5 | 1 | 100.0 | 0.0 | ||
Amikacin | 4 | 32 | 86.8 | 7.3 | 84.3 | 13.2 |
Aztreonam | 4 | 32 | 69.7 | 12.0 | 3.5 | 12.0 |
Cefepime | 2 | 16 | 79.4 | 9.0 | 79.4 | 20.6 |
Ceftazidime | 2 | >32 | 77.8 | 18.3 | 77.8 | 22.2 |
Ciprofloxacin | 0.12 | >8 | 75.8 | 21.2 | 70.7 | 29.3 |
Meropenem | 0.5 | 16 | 72.9 | 19.3 | 72.9 | 14.5 |
Piperacillin-tazobactam | 4 | 128 | 74.1 | 13.4 | 74.1 | 25.9 |
Tobramycin | 0.5 | >16 | 86.8 | 12.8 | 86.8 | 13.2 |
China (311) | ||||||
Murepavadin | 0.12 | 0.12 | ||||
Colistin | 1 | 2 | 98.4 | 1.6 | 98.4 | 1.6 |
Polymyxin B | 1 | 1 | 100.0 | 0.0 | ||
Amikacin | 4 | 16 | 90.0 | 9.0 | 86.5 | 10.0 |
Aztreonam | 8 | 32 | 65.0 | 22.2 | 3.9 | 22.2 |
Cefepime | 4 | 32 | 74.3 | 11.9 | 74.3 | 25.7 |
Ceftazidime | 4 | >32 | 74.3 | 22.8 | 74.3 | 25.7 |
Ciprofloxacin | 0.25 | 8 | 74.9 | 18.3 | 70.4 | 29.6 |
Meropenem | 1 | 16 | 69.8 | 22.2 | 69.8 | 13.8 |
Piperacillin-tazobactam | 8 | >128 | 66.2 | 19.3 | 66.2 | 33.8 |
Tobramycin | 0.5 | >16 | 83.6 | 14.8 | 83.6 | 16.4 |