TABLE 1.

PK parameters after p.o. and i.v. doses of SKLB-TB1001 (5 mg/kg) in male SD rats^a

Administration	PK parameter	U	Value	SD	CV (%)
p.o., 5 mg/kg	Tmax	h	0.833	1.01	121
	Cmax	ng/ml	151	82.5	54.6
	AUClast	h · ng/ml	586	422	72.1
	AUCINF	h · ng/ml	847	NA	NA
	Terminal t1/2	h	1.45	NA	NA
	F	%	31.5	22.6	71.8
i.v., 5 mg/kg	AUClast	h · ng/ml	1874	263	14.01
	AUCINF	h · ng/ml	1909	279	14.62
	Terminal t1/2	h	1.41	0.13	9.27
	Vss	Liters/kg	4.64	0.21	4.48
	CL	Liters/h/kg	2.66	0.39	14.74
	MRT	h	1.77	0.18	10.32

^aNA, not available (the PK parameter was not reported because the terminal phase could not be precisely determined). CV, coefficient of variation; p.o., peroral; i.v., intravenous. n = 3/time point.