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Stability in microsomes of SKLB-TB1001, M6, and M7a
| Compound | Species | Mean |
|
|---|---|---|---|
| t1/2 (min) | CLint (ml/min/kg) | ||
| Ketanserin | Human | 44.33 | 39.21 |
| Rat | 14.26 | 174.20 | |
| Mouse | 21.28 | 256.41 | |
| SKLB-TB1001 | Human | 30.96 | 56.14 |
| Rat | 19.41 | 127.94 | |
| Mouse | 22.14 | 246.51 | |
| M6 | Human | 254.06 | 6.84 |
| Rat | 50.43 | 49.25 | |
| Mouse | 36.71 | 148.67 | |
| M7 | Human | 19.48 | 89.23 |
| Rat | 7.36 | 337.53 | |
| Mouse | 7.93 | 688.49 | |
n = 3.
