TABLE 6.
Individual and mean plasma concentration-time data for metabolite M6 after a 50-mg/kg p.o. dose of SKLB-TB1001 administered to male CD1 micea
| Location | Sampling time (h) | Mean concn (ng/ml) | SD | CV (%) | Lung/plasma ratio |
|---|---|---|---|---|---|
| Plasma | 0.25 | 25.7 | 7.60 | 29.6 | 0.960 |
| 4 | 3.57 | NA | NA | 0.960 | |
| 8 | BQL | NA | NA | 0.960 | |
| 24 | BQL | NA | NA | 0.960 | |
| Lung | 0.25 | 16.8 | NA | NA | 0.960 |
| 4 | BQL | NA | NA | 0.960 | |
| 8 | BQL | NA | NA | 0.960 | |
| 24 | BQL | NA | NA | 0.960 |
a
BQL, below the quantifiable limit of 3.00 ng/ml for SKLB-TB1001 and M6 in mouse plasma and lung homogenate. NA, not available.