Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Percent TDI values for SKLB-TB1001
| Compound/isoforma | TDI (%)b |
||||
|---|---|---|---|---|---|
| 1A2 | 2C9 | 2C19 | 2D6 | 3A4 | |
| SKLB-TB1001 | 5.48 | 0.00 | 8.46 | 0.00 | 13.34 |
| Reference | 79.82 | 72.64 | 81.65 | 73.17 | 69.85 |
Reference inhibitors: furafylline for CYP1A2, tienilic acid for CYP2C9, ticlopidine for CYP2C19, mifepristone for CYP3A4, and paroxetine for CYP2D6.
Time-dependent CYP inhibition (TDI) is normalized based on the enzyme activity at 0 min of preincubation. If the calculated TDI is <0, then the TDI is 0.
