TABLE 1.
Activities of C31, ALV, and CsA against HCV replication
| Compound | Mean EC50 (μM) ± SDa |
||||||
|---|---|---|---|---|---|---|---|
| HCV-SGR |
Infectious J6/JFH1 HCV genotype 2a/2a | ||||||
| Genotype 1a | Genotype 1b | Genotype 2a | Genotype 3a | Genotype 2a/4a | Genotype 5a | ||
| C31 | 3.80 ± 1.90 | 2.95 ± 0.60 | 2.30 ± 1.20 | 7.76 ± 1.57 | 1.40 ± 1.10 | 1.20 ± 0.83 | 2.80 ± 0.40 |
| ALV | 0.04 ± 0.03 | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.02 ± 0.01 | 0.01 ± 0.002 | 0.01 ± 0.01 | 0.03 ± 0.002 |
| CsA | 0.60 ± 0.20 | 0.17 ± 0.02 | 0.20 ± 0.04 | 0.19 ± 0.12 | 0.04 ± 0.03 | 0.13 ± 0.04 | 0.06 ± 0.01 |
a
The data are shown as means ± SD of results from three independent experiments.