TABLE 1.

Mutations identified in POA-resistant mutants of M. tuberculosis that do not have known PZA resistance mutations

Gene name	Gene product	Nucleotide change	Amino acid change	POA-resistant straina
				3G1	1H2	2F9	3H4
rv1411c	Lipoprotein LprG	C672T	W224STOP	SNV	SNV	SNV	SNV
rv0521	Methyltransferase	C295T	R99W	SNV	SNV	SNV	SNV
rv3630	Hypothetical protein	G1021A	A341T		Heterogeneous (86/236 reads, 36%)	Heterogeneous (37/193 reads, 19%)
rv0010c	Hypothetical protein	T-69C			Low heterogeneity (10/99 reads, 10%)		Low heterogeneity (11/107 reads, 10%)
ppsC	Phenolpthiocerol synthesis type-I polyketide synthase C	C2284A	H762N				Low heterogeneity (12/118 reads, 10%)
cyp128	Cytochrome P450 128 (Cyp128)	T1018C	T340A				Low heterogeneity (29/228 reads, 12%)

^aSNV, single-nucleotide variant.