Figure 3. Deletion of Nampt in Thy1-YFP-Nampt−/− cKO Mice Induces Neurodegeneration in the Motor Cortex.
(A–F) Shown in (A) and (B): Nissl staining images of brain sections, including the motor cortices. (C and E) Confocal images of NeuN and MAP2 staining; (a) epi-fluorescent (top) and confocal maximal projection images (bottom); (a’) confocal single frame images. (D and F) Normalized mean NeuN and MAP2 fluorescence signals within a standardized region of interest (187 × 280 µm2 in L4/5 and hippocampus CA1 region; N = 3–5 mice). *p < 0.05; **p < 0.01, t test. Error bars represent ± SEM.
See also Figure S3.