Table 6. Risk factors for the development of torsades de pointes [34].

Risk factor	Examples
Genetic risk factors	Channelopathies
	CYP3A4 poor metaboliser
Underlying cardiac disease	Bradycardia
	Congestive cardiac failure
	Myocardial ischaemia
	Atrial fibrillation
Electrolyte derangements	Hypokalaemia
	Hypomagnesaemia
	Hypocalcaemia
Organ impairment, altering medication toxicity	Renal insufficiency
	Severe hepatic disease
Use of medication to increase QT liability	Concurrent CYP medications administered