Figure 4.

Structure of the insect ryanodine receptor and the location of resistance associated mutations. (a) Topology of the C-terminal domain of the insect RyR showing the six membrane spanning helices (TM1–6) with the positions of the two resistance mutations (I4790M & G4946E) that map to this region of the channel highlighted. (b) Shows a full model of the insect RyR based on the recently reported structure of a rabbit RyR, with the membrane domain (boxed) further magnified in (c) to show the close proximity of the resistance-associated mutations (adapted from (Steinbach et al., 2015)).