Table 5.
Modules analysis of the protein–protein interaction network
| Category | Module | Score | Nodes | Enrichment and pathway description | Genes |
| Hyper-LGs | 1 | 10.00 | 10 | GO.0005886: plasma membrane | ADRB1, VIPR1, PTGDR, SCTR, CALCA, GPR83, ADCY1, ADCY5, PTGER2, PTGER4 |
| GO.0007187: G-protein coupled receptor signaling pathway | |||||
| GO.0004016: adenylate cyclase activity | |||||
| has04080: Neuroactive ligand-receptor interaction | |||||
| 2 | 6.00 | 6 | GO.0051953: negative regulation of amine transport | CCL19, ADRA2B, P2RY12, CXCL6, NPY5R, CXCL1 | |
| GO.0008009: chemokine activity | |||||
| has04062: Chemokine signaling pathway | |||||
| 3 | 5.68 | 20 | GO.0005886: plasma membrane | OXT, SERPINE1, EDNRB, PTGS2, ADRA1A, IL18, CRP, SOCS3, EFNB3, MMP2, EPHB1, TIAM1, EFNA5, TBXA2R, EPHA2, TLR2, SNAI1, FYN, GNA14, PROK2 | |
| GO.0005003: ephrin receptor activity | |||||
| GO.0051240: positive regulation of multicellular organismal process | |||||
| hsa04360: Axon guidance | |||||
| 4 | 4.50 | 5 | GO.0005605: basal lamina | ITGA9, ITGB8, COL6A2, LAMC2, LAMA2 | |
| GO.0030198: extracellular matrix organization | |||||
| hsa04512: ECM-receptor interaction | |||||
| Hypo-HGs | 1 | 17.56 | 19 | GO.0022402: cell cycle process | CDCA5, KIF14, BRCA1, CENPF, RACGAP1, NEK2, CDKN3, DTL, MCM2, MCM10, CDC45, PTTG1, ANLN, CDC20, RRM2, AURKB, MKI67, STIL, CCNE2 |
| GO.0015630: microtubule cytoskeleton | |||||
| GO.0003688: DNA replication origin binding | |||||
| hsa04110: Cell cycle | |||||
| 2 | 5.00 | 5 | GO.0007188: adenylate cyclase-modulating G-protein coupled receptor signaling pathway | CNR1, CCL20, ADCY6, HTR1D, CCL25 | |
| hsa04062: Chemokine signaling pathway | |||||
| 3 | 4.50 | 5 | GO.0005615: extracellular space | REN, PLA2G1B, TIMP1, MMP9, VWF |
Hyper-LGs: Hypermethylated, lowly expressed genes; Hypo-HGs: Hypomethylated, highly expressed genes.