Table 1. . Antibacterial activities of compounds against staphylococcal strains.
Strains | Antibacterial activity of compounds (MIC, μg/ml) | |||||
---|---|---|---|---|---|---|
Name | Type | OZE-I | OZE-II | OZE-III | Vancomycin | Oxacillin |
Newman | MSSA | 16 | 16 | 32 | 2 | ≤0.0625 |
MW2 | MRSA | 8 | 8 | 16 | 4 | 64 |
ATCC 29213 | MSSA | 8 | 8 | 16 | 2 | 0.5 |
ATCC 33591 | MRSA | 4 | 4 | 16 | 2 | >64 |
USA100 | MSSA | 4 | 8 | 16 | 2 | ≤0.0625 |
USA300 | MRSA | 4 | 4 | 8 | 4 | >64 |
USA400 | MRSA | 8 | 8 | 16 | 2 | >64 |
MIC: Minimum inhibitory concentration; MRSA: Methicillin-resistant Staphylococcus aureus; MSSA: Methicillin-susceptible S. aureus; OZE-I: N-(5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl) cyclopropanecarboxamide; OZE-II: N-(5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)-4-((4,4-dimethyloxazolidin-3-yl) sulfonyl) benzamide; OZE-III: N-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl) pentanamide.