Table 1. . Differentially methylated loci in peripheral blood mononuclear cells associated with Montreal Cognitive Assessment.
| Chr | Position | IlluminaID | Coefficient† | p-value | Gene name (UCSC) | Gene feature | Relation_to _CpG_island |
|---|---|---|---|---|---|---|---|
| chr15 | 83953775 | cg26429925 | -0.75 | 4.71E-06 | BNC1 | TSS1500 | Island |
| chr13 | 50202570 | cg08772163 | 0.68 | 8.32E-06 | ARL11 | TSS200 | |
| chr19 | 44455454 | cg03227078 | -0.69 | 8.97E-06 | ZNF221 | 5′-UTR; 1stExon | Island |
| chr4 | 183243982 | cg18351711 | 0.93 | 1.14E-05 | ODZ3 | TSS1500 | |
| chr5 | 57756024 | cg11821403 | -0.72 | 1.28E-05 | PLK2 | TSS200 | Island |
| chr16 | 28857989 | cg05666372 | 0.65 | 2.54E-05 | TUFM | TSS1500 | Island |
| chr16 | 619677 | cg06486124 | 0.68 | 3.16E-05 | PIGQ | TSS1500 | Shore |
| chr2 | 112939562 | cg20313969 | -0.88 | 4.24E-05 | FBLN7 | Body; Body | Island |
| chr6 | 116601353 | cg02007388 | 0.68 | 4.71E-05 | TSPYL1; DSE | TSS200; 1stExon | Shore |
| chr16 | 89408076 | cg05497216 | -0.89 | 4.75E-05 | ANKRD11 | 5′-UTR | Shore |
The most significant DMPs.
†Standardized regression coefficient.
DMP: Differentially methylated position; TSS: Transcription Start Site; UCSC: University of California, Santa Cruz.