Table 2. . Differentially methylated loci in peripheral blood mononuclear cells associated with Montreal Cognitive Assessment.
| Chr | Start | Stop | Probes in DMR | p-value | Sidak-corrected p-value | Gene name (UCSC) | Gene feature | Relation_to _CpG_island | Direction of association with MoCA |
|---|---|---|---|---|---|---|---|---|---|
| chr6 | 33048253 | 33048761 | 10 | 1.53E-11 | 2.32E-08 | HLA-DPA1; HLA-DPB1 | TSS; intron; exon; 5′-UTR; CDS | Island | + |
| chr2 | 26624603 | 26625048 | 9 | 1.83E-10 | 3.16E-07 | DRC1 | TSS; intron; 5′-UTR; CDS | Island | - |
| chr1 | 57110866 | 57111123 | 6 | 1.15E-08 | 3.44E-05 | PRKAA2; LOC101929935 | TSS; 5′-UTR; CDS; intron + Exon | Island | - |
| chr11 | 15095016 | 15095179 | 6 | 4.14E-08 | 1.96E-04 | CALCB | TSS; Exon; 5′-UTR | Island | - |
| chr18 | 25757437 | 25757711 | 3 | 2.73E-07 | 7.67E-04 | CDH2 | Intergenic | Island | - |
| chr19 | 12936490 | 12936803 | 5 | 3.75E-07 | 9.21E-04 | RTBDN | Intron; UTR3; CDS; exon | Island | - |
| chr19 | 58458916 | 58459359 | 9 | 8.59E-07 | 1.49E-03 | ZNF256 | TSS; exon; 5′-UTR | Island | - |
| chr11 | 70672739 | 70672987 | 7 | 7.12E-07 | 2.21E-03 | SHANK2 | Intron | Island | - |
| chr1 | 77747373 | 77747388 | 3 | 1.75E-06 | 8.57E-02 | AK5 | Intergenic | Island | - |
| chr5 | 96038284 | 96038402 | 7 | 2.20E-05 | 1.34E-01 | CAST | Intron + UTR5; TSS + exon | Island | - |
| chr6 | 31650834 | 31651095 | 9 | 3.88E-04 | 6.82E-01 | LY6G5C | Intergenic | Island | - |
The top eight DMRs with Sidak-corrected p < 0.05 are in bold.
CDS: Coding sequence; DMP: Differentially methylated position; DMR: Differentially methylated region; MoCA: Montreal Cognitive Assessment; TSS: Transcription Start Site; UCSC: University of California, Santa Cruz.