Table 1. . Variants identified from the literature previously associated with tacrolimus trough concentrations.

rs#	Proxy SNP†	Gene	Chrom.	Position	Common name	Nucleotide	Amino acid	Ref.
rs11265572		NR1I3	1	1.61E + 08		g.161243273G>T	Noncoding	[6]
rs1800872		IL10	1	2.07E + 08	-592C>A	c.-627A>C	Noncoding	[7,8]
rs1800871		IL10	1	2.07E + 08	-819C>T	c.-854T>C	Noncoding	[7,8]
rs1800896		IL10	1	2.07E + 08	-1082G>A	c.-1117A>G	Noncoding	[9]
rs4553808	rs16840252	CTLA4	2	2.04E + 08		c.-1661A>G	Noncoding	[10]
rs3814055		NR1I2	3	1.2E + 08	-25385T>C	c.-1135C>T	Noncoding	[11,12]
rs6785049		NR1I2	3	1.2E + 08	7635A/G	c.795-93G>A	Noncoding	[13]
rs2276707	rs3814057	NR1I2	3	1.2E + 08	8055C>T	c.938-17C>T	Noncoding	[14]
rs181781	rs657075	IL3	5	1.32E + 08		c.-1285G>A	Noncoding	[10]
rs1800796	rs1524107	IL6	7	22726627		c.-636G>C	Noncoding	[15]
rs1057868		POR	7	75985688	*28	c.1508C>T	p.Ala503Val	[16–22]
rs1045642	rs2235048	ABCB1	7	87509329	3435C/T	c.3435T>C	p.Ile1145=	[12,23–29]
rs2032582	rs4148738	ABCB1	7	87531302	2677G/T/A	c.2677T/A/G	p.Ser893Ala/Thr	[12,24,27–30]
rs1128503		ABCB1	7	87550285	1236C/T	c.1236T>C	p.Gly412=	[12,24,28–30]
rs2229109	rs117937072	ABCB1	7	87550493	1199G/A	c.1199G>A	p.Ser400Asn	[30,31]
rs9282564		ABCB1	7	87600124	61A/G	c.61A>G	p.Asn21Asp	[24]
rs3213619		ABCB1	7	87600877	-129T/C	c.-129T>C	Noncoding	[13]
rs41303343		CYP3A5	7	99652770	*7	c.1035_1036insT	p.Thr346Tyrfs	[32,33]
rs10264272		CYP3A5	7	99665212	*6	c.624G>A	p.Lys208=	[32,33]
rs4646450		CYP3A5	7	99668695		c.319-1630C>T	Noncoding	[34]
rs776746		CYP3A5	7	99672916	*3	c.219-237A>G	Noncoding	[10–12,16,18,19,23,25,26,29,30,32,34–42]
rs2257401		CYP3A7	7	99709062	*2	c.1226C>G	p.Thr409Arg	[11]
rs2242480		CYP3A4	7	99763843	*1G	c.1023 + 12G>A	Noncoding	[7,10–12,29]
rs28371759		CYP3A4	7	99764003	*18B	c.875T>C	p.Leu292Pro	[43,44]
rs4646437		CYP3A4	7	99767460		c.671-205C>T	Noncoding	[7,10]
rs35599367		CYP3A4	7	99768693	*22	c.522-191C>T	Noncoding	[16,17,20,21,39,45–47]
rs2740574		CYP3A4	7	99784473	*1B	c.-392G>A	Noncoding	[42,48–51]
rs1927907		TLR4	9	1.18E + 08		c.140 + 1757C>T	Noncoding	[52]
rs4986893		CYP2C19	10	94780653	*3	c.636G>A	p.Trp212Ter	[40]
rs4244285	rs12571421	CYP2C19	10	94781859	*2	c.681G>A	p.Pro227=	[37,40,53]
rs2273697		ABCC2	10	99804058	1249G>A	c.1249G>A	p.Val417Ile	[42]
rs3740066		ABCC2	10	99844450	3972C>T	c.3972C>T	p.Ile1324=	[42]
rs2070673		CYP2E1	10	1.34E + 08		c.-333A>T	Noncoding	[37]
rs2237991		ABCC8	11	17418682		c.2223-1720T>C	Noncoding	[54]
rs5744247		IL18	11	1.12E + 08		c.-8-372C>G	Noncoding	[38]
rs1946518	rs1946519	IL18	11	1.12E + 08	A-607C	c.-838A>C	Noncoding	[41]
rs4149117		SLCO1B3	12	20858546	T334G	c.335C>A	p.Ser112Ala	[55]
rs7311358		SLCO1B3	12	20862826	G699A	c.699G>A	p.Met233Ile	[55]
rs2306283		SLCO2B1	12	21176804	A388G	c.388A>G	p.Asn130Asp	[30]
rs4149056		SLCO2B1	12	21178615	T521C	c.521T>C	p.Val174Ala	[30]
rs3745274		CYP2B6	19	41006936	*6	c.516G>T	p.Gln172His	[37]
rs2239393		COMT	22	19962905		c.289 + 90A>G	Noncoding	[56]
rs4823613	rs4253730	PPARA	22	46202410		c.208 + 3819A>G	Noncoding	[19]
rs4253728	rs4253730	PPARA	22	46214170		c.209-1003G>A	Noncoding	[19,46]

^†SNP was used as a proxy when a variant was not present in the genotyping chip.