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. 2017 Dec 20;8(1):2045893217752660. doi: 10.1177/2045893217752660

Fig. 1.

Fig. 1.

Mechanism of EC barrier auto-recovery after thrombin challenge. In parallel with rapid activation of the Rho pathway leading to increased EC permeability, thrombin causes activation of Src kinase, which stimulates the Rap1-specific GEF C3G and, via Rap1-Tiam1, turns on the Rac1 signaling. Activation of the Rap1–Rac1 signaling axis downregulates the Rho pathway of barrier disruption and promotes reassembly of AJ complexes and endothelial monolayer barrier restoration.