FIGURE 4.

RO5263397 reduces the hyperactivity in DAT-KO mice. DAT-KO mice (A) or DAT-WT mice (B) were put in the locomotor activity cages to let them habituate for 30 min. Then, mice were treated with either saline or RO5263397 at different doses and total distance traveled was measured for another 90 min. The left panel represents the dynamics of effect over all 90 min of observation. The right panel indicates the cumulative total distance calculated over the first 60 min following drug administration. All the data are shown as mean ± SEM per group (N = 8–12 per group). ^∗p < 0.05. One-way ANOVA [F(3,36) = 13.25, p < 0.001 for effect in DAT-KO mice (A); F(3,28) = 9.645, p = 0.002 for effect in DAT-WT mice (B)] followed by Dunnet’s multiple comparison test.