Table 4.

Experimental activities of the synthesized derivatives against the predicted activity according to Equations (1) and (2).

Compound	Caco-2			HepG2
	Experimental activity	Predicted activity	Residual	Experimental activity	Predicted activity	Residual
	(pIC50)	(pIC50)		(pIC50)	(pIC50)
4a	−2.2849	−2.2003	−0.0845	−1.5500	−1.5052	−0.0447
4b	−1.8253	−2.0638	0.2385	−0.9074	−0.9211	0.0137
6	—	—	—	—	—	—
8a	−0.9309	−0.8882	−0.0427	−1.4312	−1.5247	0.0935
8b	−1.9523	−1.9601	0.0078	−1.0734	−1.0444	−0.0290
8c	−1.8861	−1.8261	−0.0600	−1.4742	−1.6672	0.1930
8d	−1.2047	−1.1348	−0.0699	—	—	—
9	—	—	—	−2.2123	−2.1558	−0.0565
11a	—	—	—	−2.3118	−2.1523	−0.1595
11b	−2.1627	−2.1391	−0.0237	−1.7349	−1.9201	0.1852
11c	−2.0351	−2.0812	0.0462	−1.8603	−1.9921	0.1317
11d	−1.2058	−1.5517	0.3459	−2.3222	−2.2134	−0.1088
13a	−1.9213	−1.8689	−0.0524	−0.5416	−0.6399	0.0983
13b	−1.9852	−1.7932	−0.1920	−1.0719	−1.0082	−0.0637
15a	−2.1997	−2.1829	−0.0168	—	—	—
15b	−2.2428	−2.1671	−0.0757	−1.3992	−1.1459	−0.2533
15c	−1.6633	−1.6425	−0.0208	—	—	—