Table 2.
Characteristics of heart failure with preserved ejection fraction cohort
| HFpEF Cohort N = 80,248 |
|
|---|---|
| Demographics | |
| Age (years) | 72.5 (11.3) |
| Male (%) | 96.5 |
| Black or African American (%) | 12.3 |
| Body mass index (kg/m2) (%) | |
| Underweight (< 18.5) | 1.5 |
| Normal (18.5–24.9) | 17.4 |
| Overweight (25.0–29.9) | 27.0 |
| Obese (30.0–34.9) | 23.7 |
| Morbidly obese (≥ 35.0) | 30.3 |
| Clinical parameters | |
| Heart rate (beats per minute) | 76.2 (16.0) |
| Systolic blood pressure (mmHg) | 137.9 (23.4) |
| Diastolic blood pressure (mmHg) | 73.0 (13.2) |
| Mean LVEF (%) | 59.9 (5.9) |
| Laboratory parameters | |
| Serum sodium unit (mmol/L) | 138.8 (3.7) |
| Hemoglobin (gm/dL) | 12.4 (2.2) |
| BNP (pg/mL) | 313.5 (252.2) |
| proBNP (pg/mL) | 397.4 (292.6) |
| Serum creatinine (mg/dL) | 1.4 (1.0) |
| eGFR (ml/min/1.73m2) | 60.7 (24.9) |
| Serum potassium (mmol/L) | 4.2 (0.5) |
| Serum BUN (mg/dL) | 23.3 (10.5) |
| LDL cholesterol (mg/dL) | 89.5 (35.2) |
| HDL cholesterol (mg/dL) | 40.6 (14.0) |
| Triglycerides (mg/dL) | 143.4 (99.5) |
| Total cholesterol (mg/dL) | 157.4 (45.1) |
| Comorbidities | |
| Atrial fibrillation (%) | 26.6 |
| Stroke (%) | 6.2 |
| Hypertension (%) | 88.4 |
| Chronic liver disease (%) | 5.0 |
| Chronic obstructive pulmonary disease (%) | 47.1 |
| Chronic kidney disease (%) | 26.4 |
| Diabetes (%) | 54.3 |
| Hyperlipidemia (%) | 66.3 |
| Peripheral vascular disease (%) | 27.6 |
| Coronary artery disease (%) | 45.5 |
| Sleep apnea (%) | 16.4 |
| History of myocardial infarction (%) | 8.4S |
| PCI/CABG (%) | 5.2 |
| Medications | |
| Angiotensin converting enzyme (%) | 52.2 |
| Angiotensin receptor blocker (%) | 11.6 |
| Beta blocker (%) | 59.5 |
| Calcium channel blocker (%) | 40.3 |
| Anticoagulants (%) | 15.4 |
| Antiplatelets (%) | 11.6 |
| Digoxin (%) | 9.0 |
| Loop diuretics (%) | 69.9 |
| Thiazide (%) | 16.2 |
| Statins (%) | 53.9 |
| Nitrates (%) | 16.2 |
| Spironolactone (%) | 7.5 |
*Missing values: Race-5275; body mass index-6991; heart rate- 3681; Systolic blood pressure- 4259; Diastolic blood pressure-4259; Serum sodium-13,623; Serum potassium-13,192; Hemoglobin-33,786; Serum BUN-17,050; BNP-59,469; proBNP-76,896; Serum creatinine-14,085; eGFR-14,085; LDL cholesterol-47,133; HDL cholesterol-47,052; Triglycerides-46,795; Total cholesterol-45,165;
*Abbreviations: HFpEF heart failure with preserved ejection fraction, LVEF left ventricular ejection fraction, BNP B-type natriuretic peptide, eGFR estimated glomerular filtration rate